Yes, you can visit the Serengeti from Zanzibar. However, since the Serengeti is located in mainland Tanzania and Zanzibar is an island, you will need to take a flight from Zanzibar to the Serengeti.

The closest airport to the Serengeti is the Kilimanjaro International Airport (JRO) or Arusha Airport (ARK). From either of these airports, you can take a connecting flight to one of the Serengeti's airstrips, such as Seronera Airstrip or Ndutu Airstrip.

Alternatively, you can take a ferry from Zanzibar to Dar es Salaam on the mainland and then travel overland to the Serengeti. This would involve a long journey by car or bus, which can take up to 12 hours.

It's important to plan your trip well in advance, as Serengeti safaris can be popular and often require bookings several months ahead of time, particularly during the peak season of June to October